Erythrocyte glutathione transferase: a general probe for chemical contaminations in mammals
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چکیده
منابع مشابه
Overexpression of erythrocyte glutathione S-transferase in uremia and dialysis.
BACKGROUND Overexpression of glutathione S-transferase (GST; EC 2.5. 1.18) has been documented in the erythrocytes of patients with chronic renal failure, and this event may well be of relevance from a clinical standpoint. In fact, it could serve as a marker of uremic toxicity overall, which can contribute to impair the function and survival of the erythrocytes. However, the biochemical details...
متن کاملErythrocyte glutathione S-transferase. Electrophoretic identification of two enzyme forms.
Starch-gel electrophoresis was used to demonstrate two forms of glutathione S-transferase in human erythrocytes. Whereas considerable inter-individual differences in enzyme activity and electrophoretic patterns were detected, intra-individual differences were small.
متن کاملErythrocyte glutathione S-transferase deficiency and hemolytic anemia.
A patient with unexplained erythrocyte glutathione-S-transferase (GST) deficiency has been detected among 513 unrelated persons with hemolytic anemia. An otherwise healthy adult male, the deficient individual had a mild hemolytic anemia with splenomegaly, indirect hyperbilirubinemia, and cholelithiasis. Because he was adopted and childless, the hereditary nature of the defect could not be estab...
متن کاملErythrocyte glutathione S transferase as a marker of oxidative stress at birth.
AIMS To determine the level of oxidative stress and cell damage as a result of exposure to O(2) at birth. METHODS Using glutathione S transferase (GST) as an indicator of oxidative stress, GST activity in cord blood was compared with that in samples taken three hours after birth. Twenty four prematurely born infants and eight full term infants were studied. To test whether stronger effects oc...
متن کاملBinding of heme by glutathione S-transferase: a possible role of the erythrocyte enzyme.
Human erythrocyte glutathione S-transferase activity is inhibited, probably competitively, by hemin with a Ki of 10(-7) M. It is postulated that glutathione S-transferase functions physiologically as a hemin-binding and/or transport protein in developing erythroid cells.
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ژورنال
عنوان ژورنال: Cell Death Discovery
سال: 2016
ISSN: 2058-7716
DOI: 10.1038/cddiscovery.2016.29